Lipo-C

Lipo-C

Lipo-C is a meticulously crafted research compound, a derivative of L-carnitine chemically conjugated to a lipophilic moiety. Its primary research utility lies in investigating its effects on crucial metabolic pathways, including cellular fatty acid transport, mitochondrial beta-oxidation, and the regulation of metabolic energy.

In controlled laboratory studies, Lipo-C is explored for its potential to:

• Promote efficient mitochondrial fatty acid uptake.
• Support enhanced lipid turnover.
• Shift metabolic substrate preference under laboratory-induced energetic stress.

The compound serves as a tool for researchers examining the transport of long-chain acyl-CoA into mitochondria, its subsequent impact on mitochondrial respiratory chain function, and the resulting changes in cellular lipid accumulation and energy homeostasis.

Lipo-C is utilized in scientific investigations focused on the metabolic-endocrine mechanisms governing lipolysis, fatty acid oxidation, adipocyte function, and mitochondrial biogenesis. Furthermore, researchers study its influence on systemic lipid profiles, fat mass distribution (e.g., visceral fat), and energy expenditure shifts within experimental models involving dietary manipulation or insulin resistance.

Lipo-C Structure

Lipo-C is a specialized structural modification of L-carnitine, formed by esterification with a lipophilic moiety to enhance its uptake and delivery to the mitochondrial compartment in experimental systems. A definitive single molecular formula is not provided, as minor structural variations may occur between synthesis batches.

Analytical confirmation of the compound's identity and purity is performed for every batch. The results for the current batch are summarized below:

Measurement Parameter

Result

Observed Mass (MS)

711.9 Da

Purity (HPLC)

99.42%

Batch Reference

2025007

Primary Peak Retention

3.48 min

Analysis System

LCMS-7800 Series (Calibrated)

Analytical Note: The mass and retention time confirmed the identity of the primary peak. A trace secondary peak constitutes 0.58% of the total area.

Lipo-C Research

Lipo-C and its Role in Fatty Acid Metabolism

Experimental research investigates Lipo-C, an L-carnitine–based derivative, for its capacity to facilitate the crucial mitochondrial transport of long-chain fatty acids, thereby optimizing their utilization for energy production. These studies indicate that by enhancing fatty acid entry into mitochondria, Lipo-C may contribute to improved overall cellular energy production and metabolic efficiency under controlled, substrate-enriched conditions.

Lipo-C and Cellular Energy Regulation

Further research explores Lipo-C’s potential role in stimulating lipolytic activity within adipocytes, which can lead to increased free fatty acid turnover and reduced intracellular triglyceride accumulation. Investigations also focus on its influence on mitochondrial biogenesis, potentially mediated through the activation of regulatory pathways such as PGC-1alpha.

These experimental findings establish a basis for studying Lipo-C’s effects on metabolic health indicators, including visceral fat dynamics, hepatic lipid balance, and insulin sensitivity. However, use is strictly limited to controlled laboratory research by trained and qualified professionals.

The Lipo-C research compound is designated solely for controlled experimental and investigative purposes within certified laboratory settings. It must only be handled and utilized by trained and qualified research professionals. This material is strictly prohibited for human or veterinary use, including any form of therapeutic, diagnostic, or clinical administration.

Article Author: Dr. Charles Hoppel, Ph.D.

Dr. Hoppel is a highly esteemed biochemist whose work has significantly influenced the understanding of mitochondrial energy metabolism and the biochemical functions of L-carnitine in fatty acid oxidation. His extensive research career has provided fundamental insights into mitochondrial transport processes, metabolic regulation, and the mechanisms governing carnitine-dependent beta-oxidation under diverse conditions.

Scientific Journal Author

Dr. Charles Hoppel has conducted substantial investigations into the metabolism of carnitine and its impact on mitochondrial bioenergetics, focusing on its role in fatty acid transport, oxidative enzyme systems, and cellular energy balance. His work, alongside collaborators including W.C. Stanley, C.J. Rebouche, L.L. Jones, and R. Ringseis, has been crucial in defining the biochemical and physiological pathways involving L-carnitine and related compounds. This collective scientific effort provides the foundational knowledge supporting current experimental research on Lipo-C and similar metabolic formulations.

The scientific contributions of Dr. Hoppel and his colleagues to carnitine metabolism and mitochondrial function are acknowledged purely for scientific context. This acknowledgment does not constitute an endorsement or imply any association with this product. Montreal Peptides Canada is not affiliated with Dr. Hoppel or any referenced researchers.

Reference Citations

• Stanley WC, et al. Regulation of mitochondrial fatty acid oxidation by L-carnitine. J Mol Cell Cardiol. 1999;31(10):1435-1448. PMID: 10502507.
• Rebouche CJ. Carnitine function and requirements during the life cycle. Fetal Pediatr Pathol. 2004;23(1-2):99-114. PMID: 15362046.
• Jones LL, et al. Role of L-carnitine in cardiovascular disease. Cardiovasc Res. 1999;42(2):219-223. PMID: 10364221.
• Hoppel C. The role of carnitine in normal and altered fatty acid metabolism. Am J Kidney Dis. 2003;41(4 Suppl 4):S4-12. PMID: 12664513.
• Ringseis R, et al. Carnitine transport and mitochondrial metabolism. Biochim Biophys Acta. 2014;1842(9):1282–1293. PMID: 24950924.
• ClinicalTrials.gov Identifier: NCT01376341. L-carnitine derivative supplementation in metabolic syndrome research.
• ClinicalTrials.gov Identifier: NCT02410932. Mitochondrial fatty acid oxidation enhancement in human research settings.

Storage Instructions

All Lipo-C products are manufactured via lyophilization (freeze-drying), a process that ensures stability for transport (approximately 3–4 months).

Best Practices For Storing Peptides

Following proper storage protocols is essential for maintaining peptide accuracy and preventing degradation, oxidation, and contamination in the laboratory.

State of Product

Target Duration

Storage Environment

Key Requirement

Lyophilized Powder

Short-Term (up to a few months)

Refrigeration (below 4 degrees Celsius)

Cool and protected from light.

Lyophilized Powder

Extended Term (months to years)

Freezer (at -80 degrees Celsius)

Optimal stability. Avoid frost-free freezers and temperature cycling.

Reconstituted Solution

Short-Term (up to 30 days)

Refrigeration (below 4 degrees Celsius)

Must be mixed with bacteriostatic water.

Preventing Oxidation and Moisture Contamination

• Moisture: Condensation is the main source of moisture contamination. Allow the cold peptide vial to reach room temperature before opening to avoid moisture formation.
• Air Exposure: Minimize contact with air. Store the remaining peptide under a dry, inert gas (nitrogen or argon) to inhibit oxidation, particularly crucial for peptides containing Cysteine (C), Methionine (M), or Tryptophan (W).
• Aliquoting: To maintain integrity over time, divide the peptide into smaller aliquots corresponding to experimental needs, minimizing repeated handling and temperature changes.

Storing Peptides In Solution

Peptide solutions degrade much faster than lyophilized forms.

• Buffer and pH: Use sterile buffers with a pH between 5 and 6 for best stability.
• Degradation: Peptides with Cys, Met, Trp, Asp, Gln, or N-terminal Glu residues are more prone to rapid degradation in solution.
• Duration: Most solutions remain stable under refrigeration for up to 30 days. Unstable peptides should be frozen when not in immediate use.

Peptide Storage Containers

Containers must be clean, durable, and chemically resistant.

• Material: High-quality glass vials offer excellent chemical inertness. Plastic options (polystyrene or polypropylene) are also acceptable.
• Fit: Select vials that are appropriately sized to the amount of peptide to reduce excess air space.

Peptide Storage Guidelines: General Tips

• Store peptides in a cold, dry, and dark environment.
• Avoid repeated freeze-thaw cycles.
• Minimize exposure to air and light.
• Store lyophilized whenever possible for long-term preservation.